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Keywords: Aging
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Journal Articles

Aged Tendons Exhibit Altered Mechanisms of Strain-Dependent Extracellular Matrix Remodeling

Anthony N. Aggouras, Emma J. Stowe, Samuel J. Mlawer, Brianne K. Connizzo
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. July 2024, 146(7): 071009.
Paper No: BIO-23-1411
https://doi.org/10.1115/1.4065270
Published Online: April 17, 2024
...Anthony N. Aggouras; Emma J. Stowe; Samuel J. Mlawer; Brianne K. Connizzo Aging is a primary risk factor for degenerative tendon injuries, yet the etiology and progression of this degeneration are poorly understood. While aged tendons have innate cellular differences that support a reduced ability...
View Article titled, <span class="search-highlight">Aged</span> Tendons Exhibit Altered Mechanisms of Strain-Dependent Extracellular Matrix Remodeling
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Topics: Tendons, Stress, Biological tissues, Wounds
Includes: Supplementary data
Journal Articles

Mechanical Models of Collagen Networks for Understanding Changes in the Failure Properties of Aging Skin

Nathan J. Witt, Alan E. Woessner, Jacob Herrmann, Kyle P. Quinn, Edward A. Sander
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. July 2024, 146(7): 071002.
Paper No: BIO-23-1332
https://doi.org/10.1115/1.4064406
Published Online: March 19, 2024
...Nathan J. Witt; Alan E. Woessner; Jacob Herrmann; Kyle P. Quinn; Edward A. Sander Skin undergoes mechanical alterations due to changes in the composition and structure of the collagenous dermis with aging. Previous studies have conflicting findings, with both increased and decreased stiffness...
View Article titled, Mechanical Models of Collagen Networks for Understanding Changes in the Failure Properties of <span class="search-highlight">Aging</span> Skin
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Topics: Failure, Fibers, Skin, Stress
Includes: Supplementary data
Journal Articles

Layer-Specific Properties of the Human Infra-Renal Aorta During Aging Considering Pre/Post-Failure Damage

Dimitrios P. Sokolis
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. February 2024, 146(2): 021003.
Paper No: BIO-23-1144
https://doi.org/10.1115/1.4064146
Published Online: December 12, 2023
... the lifetime of their medial counterparts, implicating beyond 60 years the less age-varying failure properties of the intima under minimal residual compression. The positive correlation of postfailure stretch with age counteracted the declining failure stretch, serving as a compensatory mechanism against...
View Article titled, Layer-Specific Properties of the Human Infra-Renal Aorta During <span class="search-highlight">Aging</span> Considering Pre&#x2F;Post-Failure Damage
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Topics: Aorta, Failure, Stress, Kidney, Strips, Damage, Rupture
Includes: Supplementary data
Journal Articles

Induced Knockdown of Decorin, Alone and in Tandem With Biglycan Knockdown, Directly Increases Aged Murine Patellar Tendon Viscoelastic Properties

Ryan J. Leiphart, Snehal S. Shetye, Stephanie N. Weiss, Nathaniel A. Dyment, Louis J. Soslowsky
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. November 2020, 142(11): 111006.
Paper No: BIO-20-1110
https://doi.org/10.1115/1.4048030
Published Online: September 9, 2020
...Ryan J. Leiphart; Snehal S. Shetye; Stephanie N. Weiss; Nathaniel A. Dyment; Louis J. Soslowsky Tendon injuries increase with age, yet the age-associated changes in tendon properties remain unexplained. Decorin and biglycan are two matrix proteoglycans that play complex roles in regulating tendon...
View Article titled, Induced Knockdown of Decorin, Alone and in Tandem With Biglycan Knockdown, Directly Increases <span class="search-highlight">Aged</span> Murine Patellar Tendon Viscoelastic Properties
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Topics: Tendons, Viscoelasticity
Includes: Supplementary data
Journal Articles

The Effects of Stiffness, Fluid Viscosity, and Geometry of Microenvironment in Homeostasis, Aging, and Diseases: A Brief Review

Seungman Park, Wei-Hung Jung, Matthew Pittman, Junjie Chen, Yun Chen
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Review Articles
J Biomech Eng. October 2020, 142(10): 100804.
Paper No: BIO-20-1105
https://doi.org/10.1115/1.4048110
Published Online: August 31, 2020
... pathological development in the cells; pathological or aging cells, on the other hand, can alter their micro-environment to become abnormal. In this minireview, we discuss four important biophysical cues of the micro-environment—stiffness, curvature, extracellular matrix (ECM) architecture and viscosity...
View Article titled, The Effects of Stiffness, Fluid Viscosity, and Geometry of Microenvironment in Homeostasis, <span class="search-highlight">Aging</span>, and Diseases: A Brief Review
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Topics: Stiffness, Viscosity, Fluids, Diseases, Cancer
Journal Articles

The Effect of Oxidation on the Mechanical Response of Isolated Elastin and Aorta

P. Mythravaruni, Parag Ravindran
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. June 2019, 141(6): 061002.
Paper No: BIO-18-1132
https://doi.org/10.1115/1.4043355
Published Online: April 22, 2019
... Manuscript received March 10, 2018; final manuscript received March 26, 2019; published online April 22, 2019. Assoc. Editor: Seungik Baek. 10 03 2018 26 03 2019 aging oxidation mixture theory aorta elastin Muscle mass decrease and consequent compromise in function are seen...
View Article titled, The Effect of Oxidation on the Mechanical Response of Isolated Elastin and Aorta
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Topics: Aorta, Oxidation, Proteins, Constitutive equations
Journal Articles

Trabecular Bone Contributes to Strength of the Proximal Femur Under Mediolateral Impact in the Avian

N. Passi, A. Gefen
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. February 2005, 127(1): 198–203.
https://doi.org/10.1115/1.1835366
Published Online: March 8, 2005
.... A. ; and Melton , III , L. J. , 1982 , “ Changes in Bone Mineral Density of the Proximal Femur and Spine with Aging. Differences Between the Postmenopausal and Senile Osteoporosis Syndromes ,” J. Clin. Invest. , 70 , pp. 716 – 723 . Weiss , A. , Arbell , I. , Steinhagen-Thiessen , E...
View Article titled, Trabecular Bone Contributes to Strength of the Proximal Femur Under Mediolateral Impact in the Avian
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Topics: Biological tissues, Bone, Fracture (Materials), Fracture (Process), Weight (Mass), Osteoporosis, Stress, Joules