A finite element model of the bioheat transfer equation has been developed to simulate the temperature distribution in the head of a subhuman primate. Simulations were made of the induction of deep hypothermia and of subsequent hypothermic circulatory arrest (HCA). Simulations of the circulatory arrest phase were performed with different values of surface heat transfer coefficient and tissue metabolic heat generation. Numerical results were compared with experimental data for the same procedure. The simulations indicate the brain cools rapidly to a near isothermal condition in response to an infusion of cold arterial blood. However, extracerebral structures cool much more slowly. The bulk of heat gain by the brain during HCA is due to heat transfer from these warmer extra-cerebral tissues. These results suggest extended cooling by cardiopulmonary bypass (CPB) combined with surface cooling pads should reduce or even prevent the rise of brain temperatures during HCA.
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November 1985
Research Papers
Influence of Hypothermia and Circulatory Arrest on Cerebral Temperature Distributions
R. W. Olsen,
R. W. Olsen
Biomedical Engineering Program and Department of Surgery, University of Texas Health Science Center at Dallas, Dallas, Tex. 75235
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L. J. Hayes,
L. J. Hayes
Biomedical Engineering Program, University of Texas, Austin, Tex. 78712
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E. H. Wissler,
E. H. Wissler
Biomedical Engineering Program, University of Texas, Austin, Tex. 78712
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H. Nikaidoh,
H. Nikaidoh
Biomedical Engineering Program and Department of Surgery, University of Texas Health Science Center at Dallas, Dallas, Tex. 75235
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R. C. Eberhart
R. C. Eberhart
Biomedical Engineering Program and Department of Surgery, University of Texas Health Science Center at Dallas, Dallas, Tex. 75235
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R. W. Olsen
Biomedical Engineering Program and Department of Surgery, University of Texas Health Science Center at Dallas, Dallas, Tex. 75235
L. J. Hayes
Biomedical Engineering Program, University of Texas, Austin, Tex. 78712
E. H. Wissler
Biomedical Engineering Program, University of Texas, Austin, Tex. 78712
H. Nikaidoh
Biomedical Engineering Program and Department of Surgery, University of Texas Health Science Center at Dallas, Dallas, Tex. 75235
R. C. Eberhart
Biomedical Engineering Program and Department of Surgery, University of Texas Health Science Center at Dallas, Dallas, Tex. 75235
J Biomech Eng. Nov 1985, 107(4): 354-360 (7 pages)
Published Online: November 1, 1985
Article history
Received:
October 3, 1984
Revised:
July 9, 1985
Online:
June 15, 2009
Citation
Olsen, R. W., Hayes, L. J., Wissler, E. H., Nikaidoh, H., and Eberhart, R. C. (November 1, 1985). "Influence of Hypothermia and Circulatory Arrest on Cerebral Temperature Distributions." ASME. J Biomech Eng. November 1985; 107(4): 354–360. https://doi.org/10.1115/1.3138569
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