In this paper, time domain data from piezoelectric active-sensing techniques is utilized for structural health monitoring (SHM) applications. Piezoelectric transducers have been increasingly used in SHM because of their proven advantages. Especially, their ability to provide known repeatable inputs for active-sensing approaches to SHM makes the development of SHM signal processing algorithms more efficient and less susceptible to operational and environmental variability. However, to date, most of these techniques have been based on frequency domain analysis, such as impedance-based or high-frequency response functions-based SHM techniques. Even with Lamb wave propagations, most researchers adopt frequency domain or other analysis for damage-sensitive feature extraction. Therefore, this study investigates the use of a time-series predictive model which utilizes the data obtained from piezoelectric active-sensors. In particular, time series autoregressive models with exogenous inputs are implemented in order to extract damage-sensitive features from the measurements made by piezoelectric active-sensors. The test structure considered in this study is a composite plate, where several damage conditions were artificially imposed. The performance of this approach is compared to that of analysis based on frequency response functions and its capability for SHM is demonstrated.